Molecular Pathways: IDH2 Mutations—Co-opting Cellular Metabolism for Malignant Transformation
نویسندگان
چکیده
منابع مشابه
Correction: Molecular Pathways: IDH2 Mutations-Co-opting Cellular Metabolism for Malignant Transformation.
Mutations in mitochondrial IDH2, one of the three isoforms of IDH, were discovered in patients with gliomas in 2009 and subsequently described in acute myelogenous leukemia (AML), angioimmunoblastic T-cell lymphoma, chondrosarcoma, and intrahepatic chloangiocarcinoma. The effects of mutations in IDH2 on cellular metabolism, the epigenetic state of mutated cells, and cellular differentiation hav...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2015
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-15-0362